BPV


 Nevrokard™ BPV is a software package intended for analysis of blood pressure (BP) data generated by a Blood Pressure Monitor (e.g. Finometer™ PRO, Finometer™ MIDI, Portapres™,  Ohmeda Finapres™, Colin™, BIOPAC™ (e.g. NIBP100D™), ...) together with simultaneously acquired ECG data (= Heart Rate Variability /HRV/ Analysis according to the International HRV Standards*), in both time and frequency domains.

It consists of two software modules:

  • The input file for the Nevrokard BPV Analysis software module is a recorded file prepared by means of the NK File Preparation software module from ECG/BP recordings of different compatible formats (see Data Formats).

  • The Nevrokard BPV Analysis software can also analyze data series in several different compatible formats (see Data Formats).
The BP parameters analysed by the program are as follows:
  - systolic blood pressure (SBP),
- diastolyc blood pressure (DBP), 
- mean blood pressure (DBP),
- pulse pressure (PP).
 

Nevrokard™ SA-BPV is a software package for Blood Pressure Variability Analysis in small animals. It features frequency domain analysis of up to 5Hz and a resampling rate of 10Hz. It is intended for use in animals having a considerably higher heart rate than human subjects. The complementary File Preparation software for small animals is Nevrokard™ SA-NKFP software.                                                                                    

 


   
Detection of R waves, calculation of RR intervals, editing of the ECG record.



Determination of systolic (SBP) and diastolic BP (DBP), calculation of mean BP (MBP) and pulse pressure (PP), graphic display of BP, elimination of servo components by automatic interpolation.



Either whole or segmented recordings of both ECG and BP can be analysed both in time and frequency domains.



 
  TIME DOMAIN ANALYSIS of ECG (RRI) and BP (SBP, MBP, DBP)
   

Statistics: Max., Min., Max./Min., Range, Mean NN, Mean dNN (MSD), Median, 95% Conf. Interval, 99% Conf. Interval, Coef. of Variance, Variance, SDNN, SENN, SDSD, RMSSD, SDANN, SDNN Index, SDASD.

Segmented Statistics: SDANN, SDNN Index, SDASD, t-test between segments; Mean, STD, SE, 95% Confidence Interval and 99 % Confidence Interval for each segment.

Linear Regression (Trend Analysis): Coefficients A and B, R2, SEE for each segment.

Histogram: Mean, SD, Median, Modus, Dispersion, Upper F(X), Uncertainty, Skeweness, Kurtosis and Variability Index (HRV Triangular Index with a freely adjustable Class Interval (bin value)).

Poincare Analysis: SD1, SD2 in both absolute and normalized units, SD1/SD2 Ratio, CSI (Cardiac Sympathetic Index), CVI (Cardiac Vagal Index), Centroid, Ellipse Area, R2 and SEE.

 
  FREQ. DOMAIN ANALYSIS of ECG (RRI) and BP (SBP, MBP, DBP)
 
Based on the Autoregressive Model (parametric method):
  • Spectral density units: absolute, normalized.
  • Freely adjustable model order.
  • Graphic presentation and calculation of integrals of up to three preset frequency bands (ULF, VLF, LF, HF,VHF) which represent the quantitative, numeric results of spectral analysis of RRI and BP data in absolute or normalized units (absolute power of given component/[sum of absolute powers of all components-F*] x 100, *F=adjustable low frequency limit for n.u. calculation).
     
  • On-screen determination of spectral density at any frequency.
  • LF/HF ratio, LF/(LF+HF) ratio, HF/(LF+HF) ratio, CCVLF (Coefficient of Component Variance for LF) and CCVHF (Coefficient of Component Variance for HF).



Based on the FFT Algorithm (non-parametric method):
  • FFT spectra types: Amplitude (=Magnitude), RMS, Power.

  • FFT window types: Rectangular, Hanning, Hamming, Flat Top, Bartlet, Blackman, Exponent, Blackman Exact, Blackman Harris, Chebyshev, Cosine Tappered, Kaiser.

  • Spectral density units: absolute, normalized.
  • Smoothing with triangular window (freely adjustable smooth index).
  • Graphic presentation and calculation of integrals of up to three preset frequency bands (ULF, VLF, LF, HF,VHF) which represent the quantitative, numeric results of spectral analysis of RRI and BP data in absolute or normalized units (absolute power of given component/[sum of absolute powers of all components-F*] x 100, *F=adjustable low frequency limit for n.u. calculation).
  • On-screen determination of spectral density at any frequency.
  • LF/HF ratio, LF/(LF+HF) ratio, HF/(LF+HF) ratio, CCVLF (Coefficient of Component Variance for LF) and CCVHF (Coefficient of Component Variance for HF).



 
  RESULTS OF ANALYSIS
 

  • Results of analysis can be exported, directly converted into graphic formats or presentation slides, transferred to clipboard etc.




 

* Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (Marek Malik, PhD, MD, Chairman of the Writing Committee): Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use. Circulation. 1996; 93: 1043-1065.