This software package makes available both methods commonly used for BRS, the Sequence Method and the Spectral Method. It consists of two software modules:
Nevrokard™ SABRS is a software package for Baroreflex
Sensitivity Analysis in small animals.
It features frequency domain
analysis of up to 5Hz and a resampling rate of 10Hz. It is intended
for use in animals having a considerably higher heart rate than
human subjects. The complementary File Preparation software for
small animals is Nevrokard™ SABRSFP software.


Detection of R waves, calculation of RR intervals, editing of the ECG record. 
Determination of systolic (SBP) and diastolic BP (DBP), calculation of mean BP (MBP), graphic display of BP, elimination of servo components by automatic interpolation. 
Different file manipulations, zooming parts of the file, selection of RRI or HR basis, onscreen measurements of time domain parameters etc. are possible. 
Full timedomain STATISTICS is available (for RRI, HR, SBP, MBP and DBP): Max., Min., Max./Min., Range, Mean of NN, Mean of dNN (MSD), Median, 95% Conf. Interval, 99% Conf. Interval, Coef. of Variance, Variance, Std. Deviation (SDNN), Std. Error (SENN), SDSD, RMSSD 
Sequence Method of BRS 
The software calculates the BRS Index for +BP/+PI, BP/PI, All Seq. with RRI selected as the basis of calculations and for +BP/HR, BP/+HR, All Seq. with HR selected as the basis of calculations (below left), as well for all three pressures (systolic, mean, diastolic). All BRS results are displayed in a single Results Table (below right). 
In order to be included in the BRS estimate, each identified sequence must fulfill five criteria defined by the user: 1. minimal RRI change (range 010 ms) or minimal HR change (range 0.0019.999 bpm); 2. minimal BP change (range 010 mmHg); 3. minimal number of beats in the sequence (range 35 beats); 4. minimal correlation coefficient (range 01 in steps of 0.05); 5. Lag (Delay) between SBP and RRI (range 014 beats). 
Spectral Method of BRS 
FFT spectra of RRI and BP, cross spectrum and coherence are calculated and displayed (below). Results are given as LF/HF ratios for RRI and BP, as well as in the form of alphaindices for LF and HF. 
Area limits and coherence settings can be adjusted by the user (below). The frequency limits may be fixed (set in advance) or automatically defined by the result of the coherence calculation. 
RESULTS OF ANALYSIS 
